HOW TO USE APTIOM TO TREAT PARTIAL-ONSET SEIZURES

APTIOM is a once-daily prescription medicine that has been approved by the FDA to treat partial-onset seizures in patients 4 years of age and older. It is not known if APTIOM is safe and effective in children under 4 years of age.

Do not take APTIOM if you are allergic to eslicarbazepine acetate, any of the other ingredients in APTIOM, or oxcarbazepine.

3 THINGS TO KNOW ABOUT APTIOM

APTIOM is an effective medication*

When added to other anti-seizure medicines in adult clinical studies, APTIOM significantly reduced the frequency of partial-onset seizures.*

*Individual results may vary.

APTIOM IS TAKEN ONCE A DAY

It can be taken whole or crushed, with or without food.

YOU MAY BE ABLE TO SAVE ON YOUR APTIOM PRESCRIPTION

With Sunovion Answers for APTIOM®, you may pay as little as a $10 co-pay on up to 12 prescription fills per calendar year.

†Restrictions apply and co-pay amounts may vary.

LIVING BEYOND PARTIAL-ONSET SEIZURES

In this video, see how one woman doesn't let epilepsy hold her back.*

*Individual results may vary.

HOW DOES APTIOM WORK?

Partial-onset seizures occur when brain cells, called neurons, begin to fire excessively. APTIOM is believed to help reduce excessive firing.

In other words, APTIOM may help control the neurons that are causing partial-onset seizures.

Watch the video to learn more

While the precise way APTIOM works is not known, here's what we do know. When a brain cell — or neuron — fire, sodium ions must pass through voltage-gated sodium channels to propagate a brain signal. These channels have 3 different states: resting, open and inactive.

During a seizure when neurons are firing rapidly, the channels spend more time in the inactivated state. APTIOM has been shown to work preferentially on the inactivated state of the channels, the state more prevalent when a seizure is likely to occur. APTIOM is thought to bind to the inactivated state, so it may help reduce seizure-causing activity.

The precise way APTIOM works is not known.

INDICATION:

Aptiom® (eslicarbazepine acetate) is a prescription medicine to treat partial-onset seizures in patients 4 years of age and older.

IMPORTANT SAFETY INFORMATION:

Suicidal behavior and ideation: Antiepileptic drugs, including APTIOM, may cause suicidal thoughts or actions in a very small number of people, about 1 in 500. Call your doctor right away if you have any of the following symptoms, especially if they are new, worse, or worry you: thoughts about suicide or dying; attempting to commit suicide; new or worse depression, anxiety, or irritability; feeling agitated or restless; panic attacks; trouble sleeping (insomnia); acting aggressive; being angry or violent; acting on dangerous impulses; an extreme increase in activity and talking (mania); or other unusual changes in behavior or mood.

Allergic reactions: APTIOM may cause serious skin rash or other serious allergic reactions that may affect organs or other parts of your body like the liver or blood cells. You may or may not have a rash with these types of reactions. Call your doctor right away if you experience any of the following symptoms: swelling of the face, eyes, lips, or tongue; trouble swallowing or breathing; hives; fever, swollen glands, or sore throat that do not go away or come and go; painful sores in the mouth or around your eyes; yellowing of the skin or eyes; unusual bruising or bleeding; severe fatigue or weakness; severe muscle pain; or frequent infections or infections that do not go away.

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